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Leptospirosis is a water-related bacterial disease with a high incidence in Southeast Asia. People usually become infected through exposure to water contaminated by the urine of infected animals, mainly rats and mice. In the framework of the CERoPath ( 1) program, IRD researchers and their partners ( 2) have revealed the relationship between rodents’ environment and infection by leptospirosis bacteria. They showed that, whereas people mainly get infected in rice fields, the bacteria are present in a variety of environments, and particularly at the frontiers of fields and forests. The use of remote sensing and Geographic Information Systems (GIS) has helped to expand knowledge on rodents’ habitats. These studies allow a better understanding of their behaviour, depending on land use changes, and infection risks caused by human activities, including leisure.