The IRD relies on a dense and varied network of scientific partners. The Institute's work in this region is based on a system of regional cooperation rooted in co-construction and knowledge sharing. 

Due to its long-standing presence here, the Institute is highly reputed, particularly among national funding agencies. IRD research in Latin and Central America focuses on global change, sustainable management of resources and territories, and urban mobilities and dynamics. In 2019, the IRD had ten representatives here.