January 2018 - December 2021
A new natural, long-lived model, termites to study the role of feeding on aging.
Within the team "Social species in their environments: adaptation and evolution (ESEAE)" of the laboratory iEES-Paris, the researchers are studying the molecular mechanisms of aging through a new, natural model, the termite queens of the genus Macrotermes. They live at least until the age of 30 and are, throughout their life, extremely fertile (40 000 eggs / day).
Through an integrative biology approach, they study the impact of metabolic reprogramming (in response to feeding) on the reproduction rate during the development of these queens.
They will compare the data with those of infertile female workers, who have the same genome at birth but live only a few months, and those of queens of another species with very short lives.
Comparison of results with other model organisms will help to understand which molecular components are universally conserved or modified to lead to signaling pathways involved in increased longevity effects. A mathematical model will be developed using the experimental data.
- Institute of Ecology and Environmental Sciences, UMR CNRS 7618, UPEC 7618, IRD 242, INRA 1392, Paris - Créteil (France)
- Institute of Bioinformatics, School of Biological Sciences, The Westfalian Wilhelms University of Muenster (Germany)
- Department of Microbiology, Forestry and Agricultural Biotechnology Institute (FABI), University of Pretoria (South Africa)
- Dept. of Nutritional Sciences and Toxicology, University of California - Berkeley (USA)
Human Science Frontier Program (HSFP) RGP 0060/2018 - Defying the reproduction-maintenance trade-off: Role of diet in long-lived termite reproductive